African Journal of Traditional, Complementary and Alternative Medicines

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Anti-viral effect of herbal medicine Korean traditional Cynanchum paniculatum (Bge.) Kitag extracts

Woong Kim, Tae-Seok Oh, Youn-Jin Park


Background: Pestiviruses in general, and Bovine Viral Diarrhea (BVD) in particular, present several potential targets for directed antiviral therapy.

Material and Methods: The antiviral effect of Cynanchum paniculatum (Bge.) Kitag (Dog strangling vine: DS) extract on the bovine viral diarrhea (BVD) virus was tested. First, a cytotoxicity test in MDBK (Madin-Darby bovine kidney) cells was done with all organic extract concentrations.

Results: The cytotoxic concentration CC50 for the ethyl acetate (EA) extracts was 18.2 ug/ml. In the tissue culture, infectious dose (TCID50) assay, the BVD virus decreased when treated with 18.2 ug/ml of the ethyl acetate extracts.

Conclusion: Ethyl acetate extracts and fractions of the DS extract could be used as a potential antiviral for BVD.

Keywords: Antiviral, Bovine viral diarrhoea(BVD) virus, Cynanchum paniculatum (Bge.) Kitag.Ethly acetate extract

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