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Potential antitumor activity of curcumin with retinylester micro-capsuled formula

Jehan A. Khan


Background: The Bioavailabilty, efficacy and disease resistance of chemotherapy are the limitations of cancer treatment. This study was designed to formulate a microcapsules containing curcumin and retinylester as core material and tested the anti-cancer activity against different cancer cell lines.
Materials and methods: This study involved the design and formulation of microcapsules containing curcumin and retinylester as (core materials) embedded in dextrin/gelatin as wall materials. It was examined by Fourier-transform infrared spectroscopy FTIR and tested against HeLa and HepG2 cancer cell lines.
Results: Analysis of microcapsule by FTIR showed the characteristic band (2000cm-1~ 3800cm-1) that is indicated mainly from OH-, – CH3 and double bond. These bond stretching showed spectral bands peak 2975cm-1and 2670cm-1, 2836cm-1 respectively. The anticancer activity of these microcapsules on HeLA and HepG2 showed inhibition percent 87% and 85% respectively and non-toxic effect on normal cells.
Conclusion: Micro capsulated form of curcumin-retinylester showed an efficient medicinal mixture displayed a significant effect to HeLa and HepG2 cells which is very promising effective in the treatment of cancer.

Key words: Curcumin –Retinylester- Microcapsules-Anticancer

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eISSN: 0189-6016