African Journal of Traditional, Complementary and Alternative Medicines

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Hypoglycaemic and antihyperglycaemic activity of Ageratum conyzoides l. In rats.

N Nyunaï, N Njikam, E Abdenneb, J Mbafor, D Lamnaouer


The hypoglycaemic and antihyperglycaemic properties of the aqueous extracts of the leaves of Ageratum conyzoides L. were evaluated in normoglycemic and in streptozotocin-induced diabetic rats, in order to validate its use in folk medicine. Tested animals were given the aqueous extracts of the plant at the doses of 100, 200 and 300mg/kg. These doses were tested also on glucose loaded normal male rats (Oral Glucose Tolerance Test). Of all the doses, the aqueous extracts at 200 and 300mg/kg showed statistically significant hypoglycaemic and antihyperglycaemic activities. For the oral glucose tolerance test, 100mg/kg dose only attenuated significantly the rise of blood glucose in normal fasted rats. Consequently, these results confirmed the hypoglycaemic properties of the leaves of Ageratum conyzoides.

Key word: Ageratum conyzoides, hypoglycaemic activity, antihyperglycaemic activity, Oral glucose tolerance

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