Unconquerable stance of <i>plasmodium falciparum</i> depends on arrested development

Abstract

Plasmodium falciparum has conquistador prowess that depends on its knack for arrested development. This phenomenon is poorly defined/understood; therefore stakeholders neglect its relevance in malaria control strategies. This study provides requisite knowledge and motivation to interested parties to now begin to factor in arrested development of P. falciparum in order to prepare Sub Sahara Africa to strategize for malaria elimination. Reviews of published works and anecdotes were used to generate the reports embodied in this study. P. falciparum arrested development was redefined and contextualized in the light of current laboratory findings that prove that absolute arrest is incompatible with life. During arrest, metabolism is only down-regulated while essential processes continue. Arrested P. falciparum is found in all stages of its complex forms which permits it to cope with inhibitory substances thereby enabling it to exist asymptomatically while modulating some notable genes to resist chemotherapy or mobilizing the resources of the host to shield itself to frustrate host reactions. Arrested development is a defensive strategy par excellence that P. falciparum depends on for relevance in ways that are strikingly complicated. Progress in malaria control would depend on pressuring P. falciparum and its vector to change their habit through strict use of house screening. Man can also apply the principle of arrest to deal with sociopolitical problems especially in Africa.