Main Article Content
Some aryl-aryl 1H pyrazoles have been synthesised by cyclization of aryl chalcones and hydrazine hydrate in the presence of SOCl2. The yields of the pyrazoles are more than 85%. These pyrazoles are characterized by their physical constants and spectral data. The infrared, NMR spectral group frequencies of these pyrazolines have been correlated with Hammett substituent constants, F and R parameters. From the results of statistical analyses the effects of substituent on the spectral frequencies have been studied. The antimicrobial activities of all synthesised pyrazolines have been studied using Bauer-Kirby method.
KEY WORDS: SOCl2, 1H Pyrazolines, IR spectra, NMR spectra, Hammett substituent constants, Antimicrobial activities
Bull. Chem. Soc. Ethiop. 2014, 28(2), 271-288.