Reaction of ethyl acetoacetate and 2′-hydroxychalcones: Efficient route to 9-aryl-6H-benzo[c]chromen-6-ones
The reaction of ethyl acetoacetate and 2′-hydroxychalcones under atmospheric air to furnish a series of functionalized 6H-benzo[c]chromen-6-ones in moderate yields is reported. The reaction proceeds through trans-esterification, intra-molecular Michael addition, Robinson annulation and oxidative aromatization.
KEY WORDS: 2′-Hydroxychalcones, Ethyl acetoacetate, 6H-Benzo[c]chromen-6-ones, Trans-esterification, Michael addition, Robinson annulation, Oxidative aromatization
Bull. Chem. Soc. Ethiop. 2014, 28(2), 289-294.