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Silica nanoparticles as a highly efficient catalyst for the one-pot synthesis of sterically congested 2-(dibenzylamino)-2-aryl acetamide derivatives from by phthaldehyde isomers, isocyanides and dibenzylamine

A. Ramazani
Z. Shaghaghi
H. Aghahosseini
P. A. Asiabi
S. W. Joo


A green and efficient method for the preparation of 2-(dibenzylamino)-2-aryl acetamide derivatives via a three-component reaction of an isocyanide, dibenzylamine and a phthalaldehyde derivative in the presence of silica nanoparticles (silica NPs, ca. 42 nm) as a catalyst under solvent free conditions at room temperature is described. The ease of work-up, green chemistry conditions and high yields of the products make this procedure a useful addition to modern synthetic methods. The silica nanoparticles that used in this reaction as a catalyst were prepared by thermal decomposition of rice hulls. Simple, green and cheap method for the preparation of the nanocatalyst represents a major advantage for this process. The structures of these compounds were confirmed by IR, 1H and 13C NMR spectroscopy.


KEY WORDS: Silica nanoparticles, Nanocatalyst, Isocyanide, Phthalaldehyde


Bull. Chem. Soc. Ethiop. 2016, 30(3), 413-420


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eISSN: 1726-801X
print ISSN: 1011-3924