The uses of ethyl 2-(1H-benzo[D]imidazol-2-yl)acetate to synthesis pyrazole, thiophene, pyridine and coumarin derivatives with antitumor activities

  • R. M. Mohareb
  • M. S. Gamaan
Keywords: Oxobutanamide, Thiophene, Pyrazole, Pyran, Pyridine


In the present work, the ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate (3) was subjected to a series of  heterocyclization reactions through its reaction with different chemical reagents. The resulting molecules were thiophene, pyrazole, coumarin derivatives incorporated benzo[d]imidazole moiety. All the synthesized compounds were determined by elemental analysis, 1H NMR, 13C NMR, and MS. The antitumor evaluations of the newly synthesized products toward the three cancer cell lines MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer) showed that compounds 5a, 9b, 9c, 17, 23b and 38 were of the highest potencies among the synthesized compounds.


KEY WORDS: Oxobutanamide, Thiophene, Pyrazole, Pyran, Pyridine


Bull. Chem. Soc. Ethiop. 2018, 32(3), 541-557.



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eISSN: 1726-801X
print ISSN: 1011-3924