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Bulletin of the Chemical Society of Ethiopia

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2-HYDROXY-4-METHOXYBENZALDEHYDE: LARVICIDAL STRUCTURE-ACTIVITY STUDIES

Geoffrey M. Mahanga<sup>1</sup>, Teresa O. Akenga<sup>1</sup>, Wilber Lwande<sup>2</sup> , Isaiah O. Ndiege<sup>3</sup>*

Abstract


2-Hydroxy-4-methoxybenzaldehyde (1), a compound isolated from Mondia whytei (Hook) Skeels (Asclepiaceae) roots exhibited larvicidal activity (LD5022 mg/mL). A total of 18 other derivatives and closely related congeners revealed varying levels of larvicidal activity. Several closely related congeners, like 2-benzyloxy-4-methoxybenzaldehyde (2), 2-hydroxybenzaldehyde (12), 2-benzyloxybenzaldehyde (3) and benzylphenyl ether (4), showed marked improvement in activity (LD5010, 9, 4.8, 1.2 mg/mL, respectively) against Anopheles gambiae larvae. 2-Benzoyloxy-4-methoxybenzaldehyde (5) exhibited similar activity level (LD50 28 mg/mL) as 1.



KEY WORDS: 2-Hydroxy-4-methoxybenzaldehyde, Larvicides, Structure-activity relationships, 2-Hdroxybenzaldehyde, 2-Benzyloxybenzaldehyde, Benzylphenyl ether Anopheles gambiae,


Bull. Chem. Soc. Ethiop. 2005, 19(1), 61-68.



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