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Bulletin of the Chemical Society of Ethiopia

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ANTIMICROBIAL DITERPENOID ALKALOIDS FROM ERYTHROPHLEUM SUAVEOLENS (GUILL. & PERR.) BRENAN

F.N. Ngounou, R.N. Manfouo, L.A. Tapondjou, D. Lontsi*, V. Kuete, V. Penlap, F.X. Etoa, M-A.L. Dubois, B.L. Sondengam

Abstract


An investigation of the stem bark of Erythrophleum suaveolens (Guill. & Perr.) Brenan yielded the known amide norcassaide (1) and a new diterpenoid alkaloid named norerythrosuaveolide (2) which was characterized as 7β-hydroxy-7-deoxo-6-oxonorcassaide. The structures were established on the basis of one and two-dimensional 1H and 13C NMR spectral data. The compounds showed potent antimicrobial activities against bacteria and yeasts.

KEY WORDS: Erythrophleum suaveolens (Guill. & Perr.) Brenan, Norcassaide, Diterpenoid alkaloid, Norerythrosuaveolide, Antimicrobial activities, Bacteria, Yeasts


Bull. Chem. Soc. Ethiop. 2005, 19(2), 221-226.



http://dx.doi.org/10.4314/bcse.v19i2.21127
AJOL African Journals Online