ANTIMICROBIAL DITERPENOID ALKALOIDS FROM ERYTHROPHLEUM SUAVEOLENS (GUILL. & PERR.) BRENAN

  • F.N. Ngounou Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
  • R.N. Manfouo Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
  • L.A. Tapondjou Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 183, Dschang, Cameroon
  • D. Lontsi* Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
  • V. Kuete Department of Biochemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
  • V. Penlap Department of Biochemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
  • F.X. Etoa Department of Biochemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
  • M-A.L. Dubois Laboratoire de Pharmacognosie, Unité des Molécules d’Intérêt Biologique, UMIB EA3660, Faculté de Pharmacie, Université de Bourgogne, 7, Bd Jeanne d'Arc, 21079, Dijon Cedex, France
  • B.L. Sondengam Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
Keywords: <i>Erythrophleum suaveolens</i> (Guill. & Perr.) Brenan, Norcassaide, Diterpenoid alkaloid, Norerythrosuaveolide, Antimicrobial activities, Bacteria, Yeasts

Abstract

An investigation of the stem bark of Erythrophleum suaveolens (Guill. & Perr.) Brenan yielded the known amide norcassaide (1) and a new diterpenoid alkaloid named norerythrosuaveolide (2) which was characterized as 7β-hydroxy-7-deoxo-6-oxonorcassaide. The structures were established on the basis of one and two-dimensional 1H and 13C NMR spectral data. The compounds showed potent antimicrobial activities against bacteria and yeasts.

KEY WORDS: Erythrophleum suaveolens (Guill. & Perr.) Brenan, Norcassaide, Diterpenoid alkaloid, Norerythrosuaveolide, Antimicrobial activities, Bacteria, Yeasts

Bull. Chem. Soc. Ethiop. 2005, 19(2), 221-226.
Published
2005-11-22
Section
Articles

Journal Identifiers


eISSN: 1726-801X
print ISSN: 1011-3924