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Synthesis, characterization, anti-microbial and cytotoxic applications of zinc(II) complexes

M. Tariq
A. Batool
N. Abbas
A. Hussain
A. K. Qureshi
J. H. Shirazi


ABSTRACT. In the present research, three zinc(II) complexes were synthesized using 3-(3-fluorophenyl)-2-methylacrylic acid (HL), 1,10-phenanthroline and 2,2'-pyridine as ligands. The composition, structural confirmation, coordination way of ligand and assignment of geometry to the complexes were made by different analytical tools like elemental analysis, FTIR and 1H-NMR. The ligand 3-(3-fluorophenyl)-2-methylacrylate appeared to coordinate the metal (Zn) atom via COO- moiety in all of the complexes (1-3) while 1,10-phenanthroline and 2,2'-pyridine co-ordinated to Zn(II) atom through N-donor sites in complexes 2 and 3, respectively. The complex 1 showed four while 2 and 3 showed six co-ordinated geometry. The synthesized complexes were evaluated for antimicrobial and cytotoxic activities. The obtained results showed that complexes are active against microbial agents and exhibited significant cytotoxicity.


KEY WORDS: Co-coordination, Geometry, Zinc(II) complexes, Biological activity


Bull. Chem. Soc. Ethiop. 2021, 35(2), 287-299.