Iron(III) modified glassy carbon electrode for adsorption stripping voltammetric detection of uric acid

Abstract

A ferric-doped zeolite-modified electrode was fabricated for the determination of uric acid. The ferric-doped zeolite was responsible for the electrocatalytic oxidation of uric acid in a buffer solution (pH 4.6). The analytical performance of the ferric-doped zeolite modified electrode was evaluated using adsorption stripping  square wave voltammetry. A linear anodic response for uric acid in the concentration range 0.6 – 60.0 µM, a detection limit of 0.23 µM, and a sensitivity of 0.64 µA/µM were obtained. Finally, the proposed method was used for the determination of uric acid in a urine sample, and hence it has potential application for clinical samples.

KEY WORDS: Iron(III) modified electrode, Zeolite, Uric acid, Adsorption stripping square wave voltammetry

Bull. Chem. Soc. Ethiop. 2025, 39(12), 2549-2557                                                 

DOI: https://dx.doi.org/10.4314/bcse.v39i12.14