Synthesis and biological activities of O6-alkylguanine derivatives

  • Yu Lin Hu Chemical Engineering College, Nanjing University of Science and Technology, Nanjing 210094, PR China
  • Qiang Ge Chemical Engineering College, Nanjing University of Science and Technology, Nanjing 210094, PR China
  • Ming Lu Chemical Engineering College, Nanjing University of Science and Technology, Nanjing 210094, PR China
  • Hong Fei Lu Chemical Engineering College, Nanjing University of Science and Technology, Nanjing 210094, PR China
DOI: 10.4314/bcse.v24i3.60791
Keywords: O6-Alkylguanine derivatives, 2-Amino-6-chloropurine, Synthesis, Fungicidal activity

Abstract

The synthesis of some biologically active O6-alkylguanine derivatives was achieved by alkoxylation of 2-amino-6-chloropurine with sodium alkoxides in polar aprotic solvent (DMSO) conditions. The starting material 2-amino-6-chloropurine was prepared by chlorination of 2,9-diacetylguanine (obtained from acetylation of commercially available guanine) by PEG-2000 phase transfer catalysis. The structures of the products were deduced from elemental analysis and spectral data (IR, 1H NMR, and mass spectra). All the title compounds were screened for their antifungal activities, and some of the compounds showed promising activities.

 

KEY WORDS: O6-Alkylguanine derivatives, 2-Amino-6-chloropurine, Synthesis, Fungicidal activity

 

 

Bull. Chem. Soc. Ethiop. 2010, 24(3), 425-432.

Issue
Vol. 24 No. 3 (2010)
Section
Articles

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eISSN: 1726-801X
print ISSN: 1011-3924