Main Article Content

<b>Anti-inflammatory and analgesic activities: Chemical constituents of essential oils of <i>Ocimum gratissimum</i>, <i>Eucalyptus citriodora</i> and <i>Cymbopogon giganteus</i> inhibited lipoxygenase L-1 and cyclooxygenase of PGHS</b>

G. Bedi Sahouo
Z.F. Tonzibo
B. Boti
C. Chopard
J.P. Mahy
Yao T. N’guessan


The following studies report the inhibitory effect produced by chemical constituents of essential oils of three plants used in traditional medicine as anti-inflammatory and analgesic drugs, in vitro, on soybean lipoxygenase L-1 and cyclooxygenase function of prostaglandin H synthase (PGHS), the two enzymes involved in the production of mediators of inflammation. The essential oils were extracted from plants of three families: O. gratissimum (Labiatae), C. giganteus (Poaceae), and E. citriodora (Myrtaceae). Their chemical composition was established by GC/MS analyses. Among the three essential oils, one showed evident inhibition of L-1 with IC50 value of 72 µg/mL for Eucalyptus citriodora. Only one essential oil that of O. gratissimum inhibited the two enzymes, cyclooxygenase function of PGHS and lipoxygenase L-1, with an IC50 values, respectively, of 125 µg/mL and 144 µg/mL, whereas that of C. giganteus and E. citriodora, two of them had no effect on cyclooxygenase.


KEY WORDS: Essential oils, Soybean lipoxygenase (L-1), Cyclooxygenase function of

prostaglandine H synthase-1, PGHS, O. gratissimum (Labiatae), C. giganteus (Poaceae), E. citriodora (Myrtaceae), Enantia chlorantha, Inhibition



Bull. Chem. Soc. Ethiop. 2003, 17(2), 191-197.

Journal Identifiers

eISSN: 1726-801X
print ISSN: 1011-3924