Electrochemical oxidation of niclosamide at a glassy carbon electrode and its determination by voltammetry
Cyclic voltammetry, square-wave voltammetry and controlled potential electrolysis have been used to study the electrochemical oxidation behaviour of niclosamide at a glassy carbon electrode. The number of electrons transferred, the wave characteristics, the diffusion coefficient and reversibility of the reactions have been investigated. Following optimisation of voltammetric parameters, pH, and reproducibility, a linear calibration curve over the range 1 x 10-6 – 1 x 10-4 mol dm-3 niclosamide was achieved. The detection limit was found to be 8 x 10-7 mol dm-3. For eight successive determinations of 1 x 10-5 mol dm-3 niclosamide, a relative standard deviation of 3.6% was obtained. This voltammetric method was applied for the determination of niclosamide in tablets.
KEY WORDS: Niclosamide, Electrochemical oxidation, Cyclic voltammetry, Square wave voltammetry, Glassy carbon electrode, Determination of niclosamide
Bull. Chem. Soc. Ethiop. 2003, 17(1), 95-106.