One-pot three-component synthesis of 4-aryl-3,4-dihydro-pyrimidin-2(1H)-thiones catalyzed by Ni loaded SiO2

  • Suresh Maddila
  • Sreekanth B. Jonnalagadda
Keywords: Ni loaded SiO2, 4-Aryl-3, 4-dihydropyrimidin-2(1H)-thiones, One-pot three-component synthesis, Methyl 3-oxopentanoate, Aldehydes, Thiourea


A simple and efficient method has been developed for the synthesis of 4-aryl-3,4-dihydropyrimidin-2(1H)-thiones from methyl 3-oxopentanoate, aldehydes and thiourea in the presence of a catalytic amount of Ni loaded SiO2 at room temperature.

KEY WORDS: Ni loaded SiO2, 4-Aryl-3,4-dihydropyrimidin-2(1H)-thiones, One-pot three-component synthesis, Methyl 3-oxopentanoate, Aldehydes,  Thiourea


Bull. Chem. Soc. Ethiop. 2012, 26(1), 121-126.



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eISSN: 1726-801X
print ISSN: 1011-3924