Analgesic effects of the methylene chloride/methanol extract of the leaves of Laportea ovalifolia (Urticaceae)

  • AB Dongmo Laboratoire de Biologie des Organismes Animaux, Fac. Sciences, Université de Douala, BP 24157 Douala Cameroun.
  • M Ondua
  • GD Dzikouk
  • E Nguetseyazem
  • B Vouffo
  • E Bum
  • E Dongo
Keywords: <i>Laportea ovalifolia</i>, Urticaceae, analgesic activity, steroids, writhing test, formalin test.

Abstract



In the present work, the analgesic effects of methylene chloride/methanol (1:1) (CH2Cl2/CH3OH) extract of Laportea ovalifolia (Urticaceae) were evaluated using acetic acid and formalin test. The anticonvulsant effects of the same extract were also investigated on seizures induced by pentylenetetrazol (PTZ) and picrotoxin. CH2Cl2/CH3OH extract (100 -1000 mg/kg) exhibited protective effect reaching 59% of inhibition at a dose of 1000 mg/kg on the pain induced by acetic acid. The CH2Cl2/CH3OH extract significantly reduced the first phase and second phase of pain induced by formalin reaching a maximum of 98.7% of inhibition (in the late phase). The extract at the doses of 100 -2000mg/kg did not exert anti-convulsant effect neither against PTZ or PIC induced seizures.

Keywords: Laportea ovalifolia, Urticaceae; analgesic activity; steroids; writhing test; formalin test.

Cameroon Journal of Experimental Biology Vol. 4 (1) 2008: pp. 52-56
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eISSN: 1816-0573