East African Medical Journal

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Beckwith-Wiedemann Syndrome in assisted reproductive techniques: Case report

J. Wanyoike-Gichuhi, A.M. Achinga, S. Ndegwa


Assisted Reproductive Techniques (ART) is a crucial treatment for infertile couples and is frequently common. ART entails  manipulation of oocyte and sperm in a laboratory: in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI).The key  objective of ART is to yield superior quality embryos that are competent for implantation with good perinatal outcome. In spite of widespread acceptability of ART, concerns have been raised on the long-term safety of removal and manipulation of the gametes and embryos. High incidence of imprinting disorders like Beckwith-Wiedemann syndrome (BWS) have been noted in babies conceived after ART. The case report discusses BWS encountered after conception with ART and a review of other imprinting disorders associated with ART.

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