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Sexual Transmitted Infections (STIs) is among the severe form of chronic diseases affecting young age especially students in secondary school level (Ministry of Health, 2016). The purpose of this study was to investigate the knowledge and attitude towards Sexually Transmitted Disease among the students at Banisa secondary school in Banisa Sub-County Mandera County- Kenya. parents are shy to educate their adolescents on sex and sexual behaviours because of the fear that discussing sexual issues with their children might stimulate their sexual interest to practicing what they have learnt. This has resulted to them shifting the role to other agents such as the school and peer group. Richard (2008) asserted that some parents see sex education to their children as immoral due to religious beliefs that it might encourage pre-marital sex.