Potential protective effects of rosemary extract, against aspartame induced hepatotoxicity in male rats
The present study seeks to evaluate the possible protective effects of aqueous rosemary extract against aspartame overdose-induced hepatotoxicity in rats. Three groups of rats were treated orally one time /2 days for twelve weeks: first group was regarded as control, the second group was given aspartame at a dose level of 1000 mg/kg b.wt, and the third was given aspartame with the same previous dose and rosemary at a dose level of 125mg/kg b.wt. Our results showed that pretreatment with rosemary extract, produced a highly significant decrease in the elevated levels of hepatic lipid peroxidation and serum tumor necoresis factor, and the activities of aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase (P <0.01) in serum. Rosemary extract also induced a highly significant increase in serum albumin level (P < 0.01), restored the activities of antioxidant enzymes and limited histological changes of liver induced by aspartame.
Key Words: Aspartame, Rosemary extract, Toxicity, Overdose and Oxidative stress.