Lipoprotein lipase gene variants: Association with acute myocardial infarction and lipid profiles
Background: Studies showed that lipid metabolism disorders are significant risk factors for myocardial infarction and coronary artery disease (CAD). Therefore, genes involved in lipid and lipoprotein metabolism pathways such as lipoprotein lipase (LPL), are proper candidates for susceptibility to CAD.
Aim: To investigate the possible association between LPL gene variants (HindIII (rs320) and PvuII (rs285)), acute myocardial infarction (AMI) and serum lipid levels.
Subjects and methods: The study population consisted of 211 patients with a diagnosis of premature AMI, and 203 age-matched individuals with normal coronary angiograms as controls. Genotyping of HindIII and PvuII polymorphisms was done by the PCR-RFLP technique.
Results: Although the H+ and P+ alleles were more observed among the patients, there were no significant differences in genotype distributions and allele frequencies of HindIII and PvuII polymorphisms between patient and control subjects (P > 0.05). Triglyceride levels were found to be significantly elevated in H+H+ and P+P+ genotypes compared to others (P <0.05). However, there was no association between HindIII and PvuII genotypes and HDL-C, LDL-C and cholesterol levels.
Conclusion: Our findings indicate that LPL-HindIII and PvuII polymorphisms are not associated with acute myocardial infarction but with triglyceride levels.
KEYWORDS: Myocardial infarction; Lipid metabolism; Lipoprotein lipase; rs320; rs285; Polymorphism