The β fibrinogen gene G-455A polymorphism in Asian subjects with coronary heart disease: A meta analysis

Abstract

Background: There are many studies about the association of β fibrinogen gene G-455A polymorphism and the risk of coronary heart disease (CHD). However, the results of these studies are inconsistent.

Objective: This study aimed to investigate the association of β fibrinogen gene G-455A polymorphism with the risk of CHD using meta analysis. This study was limited to the Asian population.

Methods: Published studies from PubMed, Embase, and CNKI databases (up to December 20th, 2015) were searched for eligible publications. The following information was extracted from each study: (1) name of first author; (2) year of publication; (3) country of origin; (4) sample size of cases and controls, and (5) size of each allele. The combined odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association between β fibrinogen gene G-455A polymorphism and the risk of CHD were assessed using random or fixed effect model. A comprehensive meta analysis (CMA) 2.0 was used to analyze the data.

Results: Nineteen studies (4011 cases/3673 controls) regarding the association of β fibrinogen gene G-455A polymorphism and the risk of CHD were included in this meta analysis. The results indicated that β fibrinogen gene G-455A polymorphism was associated with increased (A vs. G: OR 95% CI= 1.42 [1.19–1.70], p<0.001; AA vs. GG +GA: OR 95% CI= 1.60 [1.13–2.26], p= 0.008; GA vs. GG + AA: OR 95% CI = 1.30 [1.07–1.58], p= 0.008) and decreased the risk of CHD (G vs. A: OR 95% CI= 0.70 [0.59–0.84], p <0.001; GG vs. GA +AA: OR 95% CI= 0.68 [0.55–0.84], p< 0.001).

Conclusions: In the Asian population, the β fibrinogen gene G-455A polymorphism was associated with the risk of CHD.

Keywords: β-Fibrinogen gene G-455A; Coronary heart disease; Genetic polymorphism