PROMOTING ACCESS TO AFRICAN RESEARCH

Egyptian Journal of Medical Human Genetics

Log in or Register to get access to full text downloads.

Remember me or Register



Lack of association between TRAF1/C5 rs10818488 polymorphism and rheumatoid arthritis in Iranian population

E Samadian, A Bidmeshkipour, R Gharaei, E Soleymani-Nejadian, A Shirkavand

Abstract


Rheumatoid arthritis (RA) is a multifactorial disorder related to the inflammatory response system with debilitating and painful conditions. Both genetic and environmental factors, with unknown etiology, play important roles in this disease pathogenesis. Recently, TRAF1/C5
(Tumor Necrosis Factor Receptor-Associated Factor 1/Complement Component 5) polymorphism associated with increased risk for RA has been studied in different populations worldwide, and inconsistent results have been obtained. rs10818488 allele is located on TRAF1/C5 intergenic
region, and has been predicted to be functional. A total of 100 sex- and age-matched people including RA patients (n= 50) and healthy individuals (n= 50) from Iran have been entered in this study and genotyped for rs10818488 (A/G) polymorphism, using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). In our study, rs10818488 allele was not associated with risk for RA in Iranian population (p> 0.05, OR = 1.27, 95% CI= 0.72–2.23). Results revealed that this allele might be population-specific and not to be associated with their corresponding gene pool. However, further analyses are required to clarify other RA-associated markers in our community.



AJOL African Journals Online