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Global Journal of Pure and Applied Sciences

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Mixed-Ligand Complexes Of Nickel (II) With 2-Acetylpyridine Thiosemicarbazone And Some N/S Monodentate Ligands: Synthesis, Structural Characterization And Biological Activity

GE Iniama, OE Offiong, E Nfor, AA Ayi

Abstract




The preparation and spectral properties of five nickel (II) mixed-ligands complexes (Ni [2-Actsc.Y]CI2), derived from 2-acetylpyridinethiosermicarbazones and some nitrogen/sulphur monodentate ligands such as thiophene, ammonia, picoline, pyridine and aniline are described. The complexes have been characterized on the basis of 1H and 13C-NMR, IR and electronic spectra. These revealed the primary ligand to be a tridentate thiosemicarbazone that coordinate in a square planar conformation to nickel (II) via azomethine N, pyridyl N and thiolate S atoms and a monodentate donor molecuole. The antimicrobial activities of these mixed-ligands complexes were investigated. Nickel (II) mixed-ligands complexes derived from 2-acetylpyridinethiosemicarbazones and aniline or ammonia seem to be most efficient inhibitors among these tested compounds.

Keywords: mixed-ligands complexes, square planar geometry, thiosemicarbazones, electronic spectra, biological activity.

Global Journal or Pure and Applied Sciences Vol. 14 (4) 2008: pp. 411-416



http://dx.doi.org/10.4314/gjpas.v14i4.16830
AJOL African Journals Online