Prevalence and antibiogram of extended spectrum beta-lactamase producing Klebsiella pneumoniae from urinary tract infection in general hospital, Calabar

Abstract

The rise of multidrug-resistant Klebsiella pneumoniae poses an enormous challenge to public health sector, as this leads to treatment failure for nosocomial infections. This study therefore aimed to phenotypically characterize extended spectrum beta-lactamase (ESBL) producing Klebsiella pneumoniae from urinary tract infection in General Hospital, Calabar. A total number of 17 non repetitive clinical bacterial strains were isolated, out of which (35.29 %;6/17) isolation rate falls in the age range greater than 60 years and seconded to age range 51-60 years with isolation rate of (29.41 %;5/17). Extended spectrum beta lactamase production screening revealed 23.52 %;4/17 of isolates to be ESBL producer and (76.47 %;13/17) were non-ESBL producer. The ESBL producing isolates were characterized and identified as strains of Klebsiella pneumoniae. Antibiogram of EBSL producing strains revealed, they were resistant to cefoxitin, cefotaxime, tarivid and sensitive to pefloxacin and septrin. Nevertheless, this situation has become a heavy burden in developing countries, including Nigeria, and is associated with substantial morbidity, mortality, and increased healthcare expenses