International Journal of Medicine and Biomedical Research

Log in or Register to get access to full text downloads.

Remember me or Register

Haematological evaluation of Cryptolepis sanguinolenta stem ethanolic extract in rats

AF Ajayi, RE Akhigbe, OM Adewumi, SB Olaleye


Background: The use of Cryptolepis sanguinolenta extract in medicare has gained attention since its discovery. Aim: This study sought to evaluate the haematological effect of ethanolic extract of Cryptolepis sanguinolenta stem in rat model. Materials and Methods: Control rats received 0.5ml of distilled water. Treated rats were administered oral doses of the extract at different concentrations (50, 150, and 250mg/kg body weight). All rats were maintained on a control diet. Treatment lasted for 21 days. Results: Red blood cells and haematological parameters were comparable in all groups. Similarly, total white blood cells, neutrophils and lymphocytes counts were not ignificantly altered except in rats treated with 250mg/kg/bw of the extract. However, administration of the extract led to a dose-dependent rise in platelet counts. Conclusion: This study showed that C. sanguinolenta stem ethanolic extract presents haematological challenges on white blood cells and platelets. It showed localized systemic toxicity by selectively stimulating the bone marrow.

Keywords: Cryptolepis sanguinolenta, red blood cell, white blood cell, platelet, toxicity
AJOL African Journals Online