IMTU Medical Journal

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Effect of calycopteris floribunda leaf extract on streptozotocin induced diabetic rats

AA Bhaskaran, E Sreekumaran


The anti-diabetic effect of aqueous extract of the leaves of Calycopteris floribunda (Combretaceae) was investigated in streptozotocin (STZ) induced diabetic rats. Diabetes was induced in rats by a single  intraperitoneal injection of streptozotocin (40 mg / kg body weight). The test group received single dose of the extract (500 mg / kg body weight) daily for 10 days orally. The effect of the extract on the blood glucose and urine glucose was investigated. The present study shows that the Calycopteris floribunda leaves have a significant effect on hyperglycemia and glycosuria in diabetic rats. Further studies are required to elucidate the sites, constituents involved, as well as the cellular and molecular mechanism of actions of Calycopteris
floribunda leaf extract.

KEY WORDS:Calycopteris floribunda, Streptozotocin, Diabetes mellitus, Hyperglycemia, Glycosuria

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