Determinants of severity of hyperbilirubinaemiaamong glucose-6- phosphate dehydrogenase deficient neonates in Jos north central Nigeria

Abstract

Introduction: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited disorder capable of causing severe neonatal hyperbilirubinaemia, kernicterus and death. Identifying such neonates and other factors that could aggravate their clinical states have definite place in managing them for favourable outcomes.
Materials and Methods: One hundred and fifty (150) icteric neonates admitted into the Special Care Baby Units of the Jos University Teaching Hospital, Plateau State Special Hospital and the Bingham University Teaching Hospital were recruited for this study. It was a cross sectional descriptive study conducted between March 2013 and February 2014. Parental consents were obtained and Clinical information was gathered using a questionnaire, weight were measured in grams while laboratory investigations that included Full
Blood Count (FBC), Reticulocyte Count, Serum Bilirubin (SB) Assay and G6PD activity levels were carried out.
Results: Mean age of the studied neonates at presentation was 3.28 ± 3.11 days while mean age of detection of jaundice was 2.86 ± 1.67. One hundred and five (70%) were delivered at full-term gestation (>37weeks) while 45 (30%) were delivered preterm (<37 weeks) with twenty-nine (19.3%) having history of jaundice in siblings. Fifty (35.7%) had birth weight of less than 2500g while the birth weight of 10 (6.7%) were unknown. Sixty-one of these neonates (40.7 %) were G6PD deficient with mean total serum bilirubin of 205.01 ±
96.57µmol/L.
Conclusion: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common enzyme disorder among neonates presenting with hyperbilirubinaemia which can be aggravated by other factors.

Key words: Determinants, Hyperbilirubinaemia, Glucose-6-phosphate dehydrogenase deficiency, Neonates