Oxidative Stress among Ghanaian Patients presenting with Chronic Kidney Disease

  • WKBA Owiredu
  • RKD Ephraim
  • N Amidu
  • BA Eghan Jnr
  • EF Laing
Keywords: Chronic kidney disease, dyslipidaemia, lipid peroxidation, MDA, catalase


Dyslipidaemia and lipid peroxidation are known risk factors for chronic kidney disease (CKD). This study assessed the lipid profile and oxidative stress/lipid peroxidation in CKD patient, using the oxidative stress marker, Malondialdehyde (MDA) and antioxidants; Vitamins A and C, Cata-lase and Uric Acid. The study population included 146 individuals with mean age 50.18 ± 1.14 with various CKD, s and who were undialysed. Another 80 healthy subjects without kidney pathology but of similar age and sex distribution were used as controls. With the exception of HDL-C, which showed no significant difference when CKD patients were compared with controls (1.35±0.0 5 vs 1.61±0.20, p= 0.2114, total cholesterol (TC) (4.54±0.13 vs 5.63±0.13, p=0.0274), low density lipopro-tein cholesterol (LDL-C) (106.30 ± 4.00 vs 126.30± 5.57, p=0.0134), and triglycerides (TG) (1.52± 0.08 vs 1.84±0.09, p=0.0086) increased significantly in the CKD patients. Serum MDA increased significantly (1.22 ± 0.10 vs 2.66 ± 0.07, p=0.0001) in the CKD patients as compared to the controls and increased with the severity of the condition. Vitamin A (9.76±3.03 vs 16.1±5.21, p=0.0012), Cat-alase (57.49±1.18 vs 71.98±2.91, p=0.0001) and Uric Acid (266.68±11.00 vs 333.90±10.02, p=<0.0001) increased significantly in the CKD subjects compared to controls, whilst vitamin C (0.54±0.02 vs. 0.34±0.05, p=0.0001) decreased significantly among the CKD subjects. Dyslipidaemia and in-creased oxidative stress with abnormal antioxidant levels are common in CKD patients. Therapeu-tic regimens aimed at strengthening the antioxidant defenses besides normalizing lipid concentra-tions would protect CKD patients against oxidative stress and any related complications.

Journal of Medical and Biomedical Sciences (2012) 1(1), 28-37

Keywords: Chronic kidney disease; dyslipidaemia; lipid peroxidation; MDA; catalase


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print ISSN: 2026-6294