Effect of Cola acuminate on Blood Glucose and Glycosylated Haemoglobin in Wistar Rats

  • JC Onyeanusi Department of Medial Laboratory Sciences, University of Nigeria, Enugu campus, Nigeria
  • VPO Ikpe Department of Clinical Chemistry, National Orthopaedic Hospital Enugu, Nigeria
Keywords: Kolanut diet, rat blood glucose, glycosylated haemoglobin


The levels of blood glucose and glycosylated haemoglobin (GHB) were studied in 42 Wistar rats divided into three groups; controls, group A and group B. Control rats consumed only feeds, group A consumed 0.04g of Cola acuminate, while group B consumed 0.08g of Cola acuminate mixed with their feeds daily for six consecutive weeks. Blood samples were collected weekly for analysis. Baseline values increased by 22% for blood glucose in group A and by 29% in group B. GHB also increased relatively and correlated well with blood glucose in group A (r = 0.70; P < 0.05) and in group B (r = 0.73; P < 0.05). Regular kolanut consumption elevates blood glucose and GHB levels, while withdrawal returns these parameters progressively to pre-kolanut consumption levels.
Key words: kolanut diet, rat blood glucose, glycosylated haemoglobin
Journal of Medical Laboratory Science Vol.13(1) 2004: 41 - 44

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