Effect of different aqueous extracts of garlic on some electrolytes and urea levels in rats

  • Abdulkadir Abubakar Biochemistry and Chemotherapy Division, Nigerian Institute for Trypanosomiasis Research (NITR), P.M.B. 03, Vom. Plateau State. Nigeria.
  • Chindo I Ezekiel Chemical Pathology Department, Federal College of Veterinary and Medical Laboratory Technology, National Veterinary Research Institute (NVRI), Vom. Plateau State. Nigeria.
  • Azuka T H Mokogwu Chemical Pathology Department, Federal College of Veterinary and Medical Laboratory Technology, National Veterinary Research Institute (NVRI), Vom. Plateau State. Nigeria.
  • Binta Iliyasu Chemical Pathology Department, Federal College of Veterinary and Medical Laboratory Technology, National Veterinary Research Institute (NVRI), Vom. Plateau State. Nigeria.
  • Aminu Y Bashir Chemical Pathology Department, Federal College of Veterinary and Medical Laboratory Technology, National Veterinary Research Institute (NVRI), Vom. Plateau State. Nigeria.
Keywords: Garlic, Electrolytes, Urea

Abstract

Studies on the effect of fresh and dried aqueous extracts of garlic (cold and hot) on Na+, K+, Cl-, HCO3- and urea levels of rats were carried-out. Animals were divided into 5 groups of 5 rats each. Groups I and II were treated with fresh cold and hot extract respectively, while groups III and IV received dried cold and hot extract respectively. Group V served as untreated control. Treatment was by oral administration at 100mg/kg body weight for seven consecutive days. Analysis of the results showed significant (P < 0.05) decease in Na+ and Cl- levels of the treated groups when compared with the control. However, reduction in the levels of K+ and HCO3- was insignificant (P> 0.05). The extracts appeared to have no effect on urea level when compared with the control group. The decrease observed in these electrolytes monitored were more with fresh cold extract than with others. The results therefore suggest that fresh cold garlic extract may be useful in the management of electrolyte related disorders.

Key words: Garlic; Electrolytes; Urea
Journal of Pharmacy and Bioresources Vol. 2 (1) 2004: 1-4
Published
2005-10-12
Section
Articles

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