Synthesis of dehydrodipeptides as potential suicide substrates for D, D-peptidases

  • MES Koker
Keywords: Suicide substrate, Phenoxyacyldehydrodipeptide, D, D-Peptidases

Abstract

The synthesis of the dehydrodipeptide phenoxyacyl dehydroserine–D–alanine to act as a potential suicide substrate for D, D-peptidase is presented. Starting with the hydrochloride of serine methyl ester, this was chemically transformed to the key phenoxyacyl-β–chloro Ala Ala which was dehydrohalogenated to the desired dehydrodipeptide.

Keywords: Suicide substrate, Phenoxyacyldehydrodipeptide, D, D-Peptidases

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eISSN: 0189-8442