Phytochemical analysis and toxicological evaluation of the methanolic extract of Jatropha tanjorensis leaf

  • PO Igbinaduwa
  • CO Usifoh
  • CC Ugwu
Keywords: Toxicological, Ethno toxicity, Hematological and phytochemical

Abstract

The work evaluated the behavioral and toxicological effects and its consequences on hematological parameters and the phytochemical analysis of Jatropha tanjorensis leaf. Acute and sub-acute toxicity studies were done on Wistar albino mice and rats for 14 days and 28 days respectively. Hematological parameters of the rats were also determined. During acute toxicity, there were no adverse effect found in the general behavior and mortality at any dose level given (1000-8000mg/kg b.wt.). Sub-acute toxicity did not cause any changes in the body and organ weight except a statistical decrease in the spleen weight. Hematological investigation revealed an increase in the packed cell volume, red blood cells and hemoglobin. Phytochemical analysis revealed the presence of tannins, Flavonoid, Alkaloids, Anthraquinone, Saponin and Cardiac glycosides. This work thus justifies the ethnomedicinal use of the plant in the treatment of anaemia and its safety profile.

Keywords: Toxicological, Ethno toxicity, Hematological and phytochemical

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eISSN: 0189-8442