Anticonvulsant screening and brine shrimp lethality test of some para-substituted-N-(2,6-diisopropylphenyl) benzamides

  • EO Afolabi
  • DD Barau
  • TL Agbede
Keywords: Anticonvulsant, Benzamide, Epilepsy and Seizures

Abstract

Many antiepileptic agents are available but a search for compounds with more selectivity and lower toxicity continues to be an area of intensive investigation in drug development. Among the benzamides, N-(2,6-dimethylphenyl)-4-aminobenzamide, (Ameltolide®, LY201116) is the most potent antiepileptic agent that is yet to reach the market. In view of this, some N-(2,6-diisopropylphenyl) benzamides were synthesized and screened for anticonvulsant activity in accordance with the Antiepileptic Drug Development Program (ADD) of National Institute of Health (NIH), USA. All the four compounds screened offer partial protection against chemically induced seizure of intra peritoneal metrazol on mice but the 4-chloro compound proved to be the best among the series with a protective index of 50.21 on the brine shrimp lethality test scale.

Keywords: Anticonvulsant, Benzamide, Epilepsy and Seizures.

Published
2012-08-28
Section
Articles

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eISSN: 0189-8442