PROMOTING ACCESS TO AFRICAN RESEARCH

Kenya Veterinarian

Log in or Register to get access to full text downloads.

Remember me or Register



DOWNLOAD FULL TEXT Open Access  DOWNLOAD FULL TEXT Subscription or Fee Access

Comparative Efficacy of Albenzazole, Levamisole, Rafoxanide and Ivermectin Against Naturally Acquired Gastrointestinal Nematodes in Goats

W K Munyua, R M Waruiru, J W Ngotho

Abstract




A study of the efficacy of 4 antihelmintics was carried out using a faecal egg count reduction test (FECRT) in 105 goats on breeding farm at Ol'Magogo, Naivasha, Kenya. The goats were randomly assigned to 7 groups; received 5.0 mg kg body weight albendazole (ABZ), 15 mg kg levamisole (LEV) 15 mg kg rafoxanide (RAD) orally as 2 doses 24 hours apart and 0.2mg kg Ivermectin (ivm) once orally. Other groups received albendazole and levamisole (ABZ + RAF) at the same doses and schedules as before. Faecal egg counts were measured at treatment (day 0), at 10 and 14 days afterwards. Decreasing efficacies, s measured by 3 different formulae were recorded at day 14 for IVM, ABZ and ABZ +LEV (>96%), LEV (<54%), RAF (<60%) and LEV + RAF (<65%). Calculations of 95% confidence limits indicated that resistance was present in the LEV, RAF and LEV + RAF groups. The predominant use of levamisole on the farm for a long period of time at dose rated recommended for sheep may have contributed to the development of resistance.

The Kenya Veterinarian Vol. 27 2004: pp. 5-9



http://dx.doi.org/10.4314/kenvet.v27i1.39550
AJOL African Journals Online