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<i>Carica Papaya</i> Seed Extract Enhances Cellular Response to Stress in U

O Dosumu
A Chionna
P Pagliara
O Akinola
L Dini


Cell death via apoptosis is involved in a wide range of biological and pathological processes and has been associated with oxidative stress in a number of cell systems. Therefore, the present study was carried out to investigate the role of Carica papaya seed (CPS) extract that contains, Benzyl Isothiocyanates, one of the inducers of phase II enzymes in the regulation of cellular stress. The cellular responses were observed in U937 cells (human monocyte/macrophage cell line) at the concentration: 200, 500 and 1000µg/mI (PPM) for 24–48 hours. Results indicated that the cells cultured with different concentration of CPS extract at all dose regimen had lower population of apoptotic/transformed cells in a dose dependent manner, with active proliferation of cells.

Key Words: U937 cells; Carica papaya. Benzyl Isothiocyanates; apopotosis

Nig. J. Health and Biomed. Sciences Vol.2(2) 2003: 94-97

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eISSN: 1595-8272