Carica Papaya Seed Extract Enhances Cellular Response to Stress in U

  • O Dosumu Department of Anatomy, Faculty of Health Sciences, University of Ilorin, P.M.B. 1515, Nigeria
  • A Chionna Laboratory for comparative Anatomy, Department of Biological Sciences, University of Lecce, Via per Monteroni, 73100, Lecce, Italy
  • P Pagliara Laboratory for comparative Anatomy, Department of Biological Sciences, University of Lecce, Via per Monteroni, 73100, Lecce, Italy
  • O Akinola Department of Anatomy, Faculty of Health Sciences, University of Ilorin, P.M.B. 1515, Nigeria.
  • L Dini Laboratory for comparative Anatomy, Department of Biological Sciences, University of Lecce, Via per Monteroni, 73100, Lecce, Italy.
Keywords: U937 cells, Carica papaya. Benzyl Isothiocyanates, apopotosis

Abstract

Cell death via apoptosis is involved in a wide range of biological and pathological processes and has been associated with oxidative stress in a number of cell systems. Therefore, the present study was carried out to investigate the role of Carica papaya seed (CPS) extract that contains, Benzyl Isothiocyanates, one of the inducers of phase II enzymes in the regulation of cellular stress. The cellular responses were observed in U937 cells (human monocyte/macrophage cell line) at the concentration: 200, 500 and 1000µg/mI (PPM) for 24–48 hours. Results indicated that the cells cultured with different concentration of CPS extract at all dose regimen had lower population of apoptotic/transformed cells in a dose dependent manner, with active proliferation of cells.

Key Words: U937 cells; Carica papaya. Benzyl Isothiocyanates; apopotosis

Nig. J. Health and Biomed. Sciences Vol.2(2) 2003: 94-97

Author Biography

O Dosumu, Department of Anatomy, Faculty of Health Sciences, University of Ilorin, P.M.B. 1515, Nigeria
Department of Anatomy, Faculty of Health Sciences, University of Ilorin, P.M.B 1515 Ilorin, Nigeria.
Published
2004-03-15
Section
Articles

eISSN: 1595-8272