PHARMACOLOGICAL PROPERTIES OF SECURIDACA LONGIPEDUNCULATA ON VASCULAR AND EXTRA-VASCULAR SMOOTH MUSCLES

  • John AO Ojewole Department of Pharmacology; Faculty of Health Sciences, University of Durban-Westville, Private Bag X54001, Durban 4000, South Africa
  • Gbola Olayiwola Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria
  • Olapade RS Ilesanmi Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria
Keywords: Securidaca longipedunculata, Polygalaceae, Root Bark, Vascular and Extra-vascular Smooth Muscles, Inhibitory Effects, Non-specific Action

Abstract

Methanolic Extract of the root-bark of Securidaca longipedunculata was tested for pharmacological activity on isolated vascular and extra-vascular smooth muscle preparations. The root barks extract (50-800mg/ml) inhibited and/or abolished, in a concentration-dependent manner, the myogenic, spontaneous contractions as well as standard agonist drug-induced contractions of the smooth muscles preparations used. The rat isolated portal vein, rat isolated aortic ring, and guinea pig isolated ileum and guinea pig isolated uterus were employed in the in-vitro experiments. Since the plant extract inhibitory effects of the plant extract are unlikely to be mediated thorugh a specific receptor system, but rather, through a non-specific spasmolytic action.

Key Words: Securidaca longipedunculata; Polygalaceae, Root Bark; Vascular and Extra-vascular Smooth Muscles; Inhibitory Effects; Non-specific Action

Nig. J. Nat Prod. And Med. Vol.5 2001: 26-29
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