ANALGESIC AND ANTIPYRETIC ACTIONS OF ENANTIA CHLORANTHA EXTRACT IN SOME LABORATORY ANIMALS

  • EO Agbaje Department of Pharmacology, College of Medicine, P.M.B. 12003, Lagos, Nigeria
  • AO Onabanjo Department of Pharmacology, College of Medicine, P.M.B. 12003, Lagos, Nigeria
Keywords: Enantia chlorantha, Anonaceae, malaria, fever, pain, Klesbsiella sp., mice and rabbits

Abstract

Aqueous extract of the bark of Enantia chlorantha administered intraperitoneally (i.p) into healthy adult albino mice at does of 1.0 and 5.0g/kg resulted in elevation of pain threshold. The action of E. chlorantha was found to be about 20 times less potent than morphine. On the other hand, a dose if 15.0g/kg of the extract given orally to rabbits infected with Klebsiella sp was able to relieve the pyrogenic induced fever whereas no such effect was observed in the control group that was given ordinary water.

Key Words: Enantia chlorantha, Anonaceae, malaria, fever, pain, Klesbsiella sp., mice and rabbits

Nig. J. Nat. Prod. And Med. Vol.2 1998: 24-25
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