EFFECT OF BRIDELIA FERRUGUBEA STEM BARK ON BLOOD CHEMISTRY AND HISTOLOGY OF SOME ORGANS IN RATS

  • CJ Ofogba Department of Chemistry, College of Medicine University of Lagos.
  • FU Agbomo National Institute for Medical Research, Yaba, Lagos
  • FB Abdul-Kareem Morbid Anatomy, College of Medicine University of Lagos.
  • AM Abaelu Department of Chemistry, College of Medicine University of Lagos.
  • K Alatishe Department of Chemistry, College of Medicine University of Lagos.
Keywords: Bridelia ferruginea, Euphorbiaceae, blood chemistry, rat lungs and heart

Abstract

Aqueous extract of Bridelia ferruginea stem bark caused significant increases in serum K+, creatinine, total bilirubin, GOT, GPT, HDL, Alkaline phosphate, BUN (p<0.001) and decreases in serum Na+, Cl-, CO2), cholesterol, glucose, Ca2+ (p<0.01,0.001) in rats. No changes were observed in serum triglyceride, uric acid, phosphate and total protein levels when compared with the control. The increase in some if these parameter was detected by means of PAS staining. The heart and lungs also showed adverse effects.

Key Words: Bridelia ferruginea, Euphorbiaceae, blood chemistry, rat lungs and heart

Nig. J. Nat. Prod. And Med. Vol.2 1998: 26-28
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eISSN: 1118-6267