Antidiabetic Activity Of Cassia auriculata Seeds In Alloxan Induced Diabetic Rats

  • SS Jalalpure Department of Pharmacognosy, Kles College of Pharmacy, JNMC campus, Nehru Nagar Belgaum 590010, Karnataka, India
  • MB Patil Department of Pharmacognosy, Kles College of Pharmacy, JNMC campus, Nehru Nagar Belgaum 590010, Karnataka, India
  • Aruna Pai Department of Pharmacognosy, Kles College of Pharmacy, JNMC campus, Nehru Nagar Belgaum 590010, Karnataka, India
  • BN Shah Department of Pharmacognosy, Kles College of Pharmacy, JNMC campus, Nehru Nagar Belgaum 590010, Karnataka, India
  • MD Salahuddin Department of Pharmacognosy, Kles College of Pharmacy, JNMC campus, Nehru Nagar Belgaum 590010, Karnataka, India
Keywords: ><i>Cassia auriculata</i> seeds, Caesalpiniaceae, Blood glucose level, Tolbutamide and Petroleum ether extract

Abstract

The petroleum ether (40-60 ºC), chloroform, ethyl acetate, ethanol and aqueous extracts of Cassia auriculata seeds, obtained by soxhlet extraction method were evaluated for antidiabetic activity using alloxan (60 mg/kg through tail vein) induced hypoglycemic rats on acute and prolonged treatment. The potency of extracts was compared with that of standard tolbutamide (250 mg/kg body weight, p.o.). Petroleum ether and ethyl acetate extracts showed highly significant (p<0.001) antidiabetic activity in both acute and prolonged treatment studies. The results were comparable to standard drug tolbutamide.
Key words:Cassia auriculata seeds, Caesalpiniaceae, Blood glucose level, Tolbutamide and Petroleum ether extract.
Nig. J. Nat. Prod. and Med. Vol.8 2004: 22-23
Published
2005-06-23
Section
Articles