Anti-Hepatotoxic Activity Of Indigofera tinctoria

  • R Ravi Natural Products Research Laboratory, 1Department of Pharmaceutics. S.B. College of Pharmacy, Sivakasi-626 130.Tamil nadu, India
  • R Venkatanarayanan Natural Products Research Laboratory, 1Department of Pharmaceutics. S.B. College of Pharmacy, Sivakasi-626 130.Tamil nadu, India
  • R Binokingsly Natural Products Research Laboratory, 1Department of Pharmaceutics. S.B. College of Pharmacy, Sivakasi-626 130.Tamil nadu, India
  • R Hemalatha Natural Products Research Laboratory, 1Department of Pharmaceutics. S.B. College of Pharmacy, Sivakasi-626 130.Tamil nadu, India
  • TNK Suriyaprakash Natural Products Research Laboratory, 1Department of Pharmaceutics. S.B. College of Pharmacy, Sivakasi-626 130.Tamil nadu, India
  • SM Sivakumar Natural Products Research Laboratory, 1Department of Pharmaceutics. S.B. College of Pharmacy, Sivakasi-626 130.Tamil nadu, India
  • S Sathesh Kumar Natural Products Research Laboratory, 1Department of Pharmaceutics. S.B. College of Pharmacy, Sivakasi-626 130.Tamil nadu, India
Keywords: <I>Indigofera tinctoria</I>, Papilonaceae, anti-hepatotoxic, carbon tetrachloride, silymarin, Serum Glutamate Pyruvate Transaminase, Serum Glutamate Oxaloacetate Transaminase

Abstract

The methanol extract of Indigofera tinctoria (50mg/kg p.o) significantly reduced Serum Glutamate Pyruvate Transaminase SGPT (84.6± 6.31) and Serum Glutamate Oxaloacetate Transaminase SGOT (78.83± 3.96) levels from SGPT (126.33±6.88) and SGOT (114.33±6.88) levels in the CCl4 (1.25ml/kg b.w.p.o) induced hepatic damage in rats. The control groups (vehicle: 4%w/v aqueous acacia mucilage) had SGPT and SGOT was 32.83±4.88 and 46.33±6.88 respectively. The Antihepatotoxic activity of Indigofera tinctora was comparable with standard drug silymarin (100mg/kg. p.o.) with SGPT and SGOT of 47±6.16 and 59.33±6.31 respectively.
Key words: Indigofera tinctoria, Papilonaceae, anti-hepatotoxic, carbon tetrachloride, silymarin,Serum Glutamate Pyruvate Transaminase,Serum Glutamate Oxaloacetate Transaminase.
Nig. J. Nat. Prod. and Med. Vol.8 2004: 43-44
Published
2005-06-23
Section
Articles

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eISSN: 1118-6267