The Antidiabetic Potential Of Jatropha tanjorensis Leaves

  • G. Olayiwola Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria
  • EO Iwalewa Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria
  • OR Omobuwajo Department of Pharmacognosy, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria
  • AC Adebajo
  • AA Adeniyi Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria
  • EJ Verspohl Department of Pharmacology, Institute of Pharmaceutical and Medicinal Chemistry, Westfälische Wilhelms - Universität, D-48149 Münster, Germany
Keywords: Anti-hyperglycaemic, Hypoglycaemic effects, INS-1 cells, Jatropha tanjorensisi

Abstract

In Southwest Nigeria, infusion of Jatropha tanjorensisi leaves is taken orally for the treatment of diabetic symptoms. The hypoglycemic effect of EtOH/H2O (1:1) leaf extract was evaluated in fasted and glucose-loaded rats at the doses of 1 and 2g/kg in-vivo, while three fractions of the extract were assessed for their anti-diabetic potentials in-vitro to stimulate the release of insulin secretion from INS–1 cells. Only 2 g/kg of the extract possesses significant glucose lowering activity in glucose-loaded rats while the insulin secretion ability in-vitro was limited to the ethylacetate fraction.
Key words: Anti-hyperglycaemic, Hypoglycaemic effects; INS-1 cells; Jatropha tanjorensisi.
Nig. J. Nat. Prod. and Med. Vol.8 2004: 55-58
Published
2005-06-23
Section
Articles

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