Eniotorin, An Anti-Malarial Coumarin From The Root Bark Of <i>Quassia undulate</i>

Abstract

The chloroform soluble portion of methanolic extract of the root bark of Quassia undulata Simaroubaceae, gave four compounds: scopoletin 1, glaucarubinone 2, 15-desacetylundulatone 3 and a new coumarin, eniotorin 4. The structures were determined by analysis of the spectroscopic data. The aqueous extract and the isolated compounds exhibited dose-related effect against the P. falciparum malaria parasite in an in-vitro antimalarial assay.

Key words: Eniotorin, Quassia undulata, Simaroubaceae, anti-malaria, simaroubaceae.

Nig. J. Nat. Prod. and Med. Vol.8 2004: 69-73