Eniotorin, An Anti-Malarial Coumarin From The Root Bark Of Quassia undulate

  • JK Adesanwo Discipline of Chemistry, School of Physical Sciences, University of KwaZulu-Natal, Westville Campus, P/Bag X54001, Durban 4000, South Africa
  • O Ekundayo Department of Chemistry, University of Ibadan, Nigeria
  • FO Shode Discipline of Chemistry, School of Physical Sciences, University of KwaZulu-Natal, Westville Campus, P/Bag X54001, Durban 4000, South Africa
  • VCO Njar Departmenof Pharmacology & Expt. Therapeutics, University of Maryland, Baltimore School of Medicine, 655 West Baltimore Street Baltimore, MD 21202-1559 U.S.A
  • AJJ van den Berge Department of Medicinal Chemistry, Faculty of Pharmacy, Universiteit Utrecht, P.O. Box 80082, 3508 TB Utrecht, The Netherlands
  • AT Oludahunsi Postgraduate Institute for Medical Research and Training (PIMRAT), College of Medicine, University of Ibadan, Nigeria
Keywords: Eniotorin, <i>Quassia undulata</i>, Simaroubaceae, anti-malaria, simaroubaceae

Abstract

The chloroform soluble portion of methanolic extract of the root bark of Quassia undulata Simaroubaceae, gave four compounds: scopoletin 1, glaucarubinone 2, 15-desacetylundulatone 3 and a new coumarin, eniotorin 4. The structures were determined by analysis of the spectroscopic data. The aqueous extract and the isolated compounds exhibited dose-related effect against the P. falciparum malaria parasite in an in-vitro antimalarial assay.
Key words: Eniotorin, Quassia undulata, Simaroubaceae, anti-malaria, simaroubaceae.
Nig. J. Nat. Prod. and Med. Vol.8 2004: 69-73
Published
2005-06-23
Section
Articles

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eISSN: 1118-6267