Nigerian Journal of Natural Products and Medicine

Log in or Register to get access to full text downloads.

Remember me or Register

The AJOL site will be undergoing a major upgrade over the next couple of days.

During this period there will temporarily be some restrictions to the available functionality.
  • Users will not be able to register or log in during this period.
  • downloads of full text (PDF) subscription based journal articles will NOT be available
  • full text (PDF) downloads of Open Access journal articles will be available as always
We apologise for any inconvenience caused. Please check back soon, as we will revert to usual policy as soon as possible.
DOWNLOAD FULL TEXT Open Access  DOWNLOAD FULL TEXT Subscription or Fee Access

Prostaglandin E2 (PgE2) Inhibition By Crude Extracts Of Selected Medicinal Plants From Botswana

D M Motlhanka, S Habtermariam


This study was undertaken to assess anti-inflammatory activity of crude extracts of Cassine transvaalensis Burtt-Davy, Clerodendrum uncinatum Schinz and Commiphora glandulosa Schinz using COX inhibition assay. Water extract of C. transvaalensis root bark (125mg/ml) exhibited a (90%) PGE2 inhibition in lipopolysaccharide (LPS) induced RAW 264.7 macrophages. This was a very good anti-inflammatory activity comparable to the control drug indomethacin (100%) at 0.4mg/ml. Chloroform extracts of C. uncinatum root (1.25mg/ml) and C. glandulosa stem resin (1.25mg/ml) exhibited good PGE2 inhibition (44% and 38%) respectively.

Keywords: Anti-inflammatory activity; PGE2 inhibition; LPS induced Raw 264.7 macrophages; Botswana plants.

Nigerian Journal of Natural Products and Medicine Vol. 11 2007 pp. 32-33
AJOL African Journals Online