PROMOTING ACCESS TO AFRICAN RESEARCH

Nigerian Journal of Natural Products and Medicine

Log in or Register to get access to full text downloads.

Remember me or Register



DOWNLOAD FULL TEXT Open Access  DOWNLOAD FULL TEXT Subscription or Fee Access

Prostaglandin E2 (PgE2) Inhibition By Crude Extracts Of Selected Medicinal Plants From Botswana

D M Motlhanka, S Habtermariam

Abstract




This study was undertaken to assess anti-inflammatory activity of crude extracts of Cassine transvaalensis Burtt-Davy, Clerodendrum uncinatum Schinz and Commiphora glandulosa Schinz using COX inhibition assay. Water extract of C. transvaalensis root bark (125mg/ml) exhibited a (90%) PGE2 inhibition in lipopolysaccharide (LPS) induced RAW 264.7 macrophages. This was a very good anti-inflammatory activity comparable to the control drug indomethacin (100%) at 0.4mg/ml. Chloroform extracts of C. uncinatum root (1.25mg/ml) and C. glandulosa stem resin (1.25mg/ml) exhibited good PGE2 inhibition (44% and 38%) respectively.

Keywords: Anti-inflammatory activity; PGE2 inhibition; LPS induced Raw 264.7 macrophages; Botswana plants.

Nigerian Journal of Natural Products and Medicine Vol. 11 2007 pp. 32-33



http://dx.doi.org/10.4314/njnpm.v11i1.11876
AJOL African Journals Online