PROMOTING ACCESS TO AFRICAN RESEARCH

Nigerian Journal of Natural Products and Medicine

Log in or Register to get access to full text downloads.

Remember me or Register



DOWNLOAD FULL TEXT Open Access  DOWNLOAD FULL TEXT Subscription or Fee Access

Hepatoprotective Action Of Cordia dichotoma Against Carbon Tetrachloride Induced Liver Injury In Rats

K Thirupathi, S Sathesh Kumar, P Goverdhan, B Ravikumar, D Krishna, G Krishna Mohan

Abstract




The methanolic extract of the leaves of Cordia dichotoma at 300 mg/kg and 500 mg/kg were studied for hepatoprotective action in male Wistar rats by inducing liver damage using carbon tetrachloride (CCl4). Silymarin was used as standard drug. The extract (300 mg/kg) significantly reduced the AST (P<0.001), ALT (P<0.001) and TBR levels (P<0.01) and at 500 mg/kg dose significantly reduced the AST (P<0.001), ALT (P<0.001), TBR (P<0.01) and lipid peroxide levels (P<0.05). The antioxidant parameters like glutathione and total antioxidant levels increased considerably although they were statistically insignificant. The hepatoprotective activity of C. dichotoma was comparable with silymarin (100mg/kg).

Keywords: Cordia dichotoma Linn., Boraginaceae, carbon tetrachloride; serum enzyme levels; antioxidants; hepatoprotective activity.

Nigerian Journal of Natural Products and Medicine Vol. 11 2007 pp. 37-40



http://dx.doi.org/10.4314/njnpm.v11i1.11878
AJOL African Journals Online