Diuretic Activity Of Leaf Extracts Of Andrographis lineata
The diuretic activity of methanol and aqueous extracts of Andrographis lineata were evaluated by determination of urine volume, electrolyte concentration and diuretic potency in male Wister rats with frusimide was used as reference drug and normal saline solution as control. The urine out put increased with both extracts indicating a dose dependent diuretic activity. Both extracts caused marked increase in Na+, K+ and Cl- levels in urine. The results supported the folkloric claim that the plant has a diuretic activity. They also increased rat locomotor activity significantly when compared to the control saline and the level was similar to that of caffeine.
Keywords: Andrographis lineata, Acanthaceae, diuretic activity, Frusimide
Nigerian Journal of Natural Products and Medicine Vol. 11 2007 pp. 61-63