The study was carried out to investigate the anti-ulcer activity of aqueous leaf extract of Persea americana. Groups of albino rats were pre-treated orally with aqueous leaf extract of the plant before administration of the ulcerogenic drugs-indomethacin and ethanol. The animals were sacrificed by a blow on the head, their stomachs removed and examined for ulcers. The extract produced significant (P<0.05), and dose-dependent anti-ulcer activity against indomethacin- and ethanol-induced ulcers in rats. Phytochemical studies revealed the presence of alkaloids flavonoids, saponins and tannins. These results suggest that the extract possesses significant anti-ulcer activity against experimentally induced gastric lesions and may justify its use in traditional medicine.
Key words: Anti-ulcer activity; Persea Americana; Rats
Nig. J. Pharm. Res. 3(1) 2004: 91-95