Identification of the Hydrolytic Degradation Product of Irbesartan in Aqueous Solution

  • CJ Mbah

Abstract

The hydrolytic degradation of irbesartan in borate buffer (pH 9.80) at 70 ± 1° C was studied. The degradation was hydroxide ion catalyzed. The separation of irbesartan from the degraded product was achieved by high performance liquid chromatography. The isolated degraded product was confirmed by its retention time. The characterization was done by elemental and infrared spectroscopic analyses. The characterized degraded product is methyl-biphenyltetrazole.

Keywords: hydrolysis, degradation, irbesartan, aqueous solution, buffer

Nigerian Journal of Pharmaceutical Research, Vol. 8 No 1 pp. 43 - 45 (September 2010)

Author Biography

CJ Mbah
Department of Pharmaceutical and Medicinal Chemistry University of Nigeria, Nsukka
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Articles

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eISSN: 0189-8434