Toxicological studies of silver nanoparticles synthesized from Calopogonium mucunoides aqueous leaf extract on Wistar rats

  • A.S. Adedeji
  • F.A. Kuta
  • J.O. Tijani
  • N.U. Adabara
Keywords: Alterations, nanosilver, toxicity, upsurge.


Increasing usage of nanosilver (AgNPs) for biomedical purposes outstrips the handiness of safety evaluation studies. This study investigates oral toxicity of biogenic AgNPs (at 50, 75, 100 and 150 μg/kg) on rats. Results analysis revealed that C. mucunoides AgNPs improved dietary intake and body weight of rats. Level of serum total protein significantly increased 9.54±0.05, 8.31±0.06, 11.31±0.41, 10.48±0.65 g/dL compared to control 6.43±0.55 g/dL while serum AST significantly reduced to 0.05±0.00 and 0.10±0.02U/L at 50 and 75 μg/mL. AgNPs did not significantly (P ˃ 0.05) altered serum chloride, urea, ALT and creatinine relative to the control. However, serum potassium (10.74±1.86 mmol/l) significantly decreased (P < 0.05) to 3.11±0.71, 3.12±2.50 4.64±1.47, 5.79±1.30mmol/L respectively. There was also a significant (P < 0.05) dose dependent upsurge in platelets (618.50±48.79, 743.50±17.68, 763.50±10.60 and 843.50±24.75) and MCV (49.50±0.71, 52.50±0.71, 53.50±0.71 and 56.00±4.24) compared to the control (617.50±79.90 and 43.00±0.00) respectively. The haemoglobin, PCV, MCHC, MCH, RBC, WBC, lymphocytes, monocytes, eosinophils and basophils values were not different (P ˃ 0.05) from the control. Results obtained suggest that AgNPs is relatively safe, although it altered serum total protein and potassium concentrations, no rat died due toxicological effect.

Keywords: Alterations, nanosilver, toxicity, upsurge.


Journal Identifiers

print ISSN: 0795-5111