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Nigerian Medical Journal

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Free radical scavenging enzymes, activities and their correlation with malondialdehyde in actue infective Hepatitis patients

S Mishra, A Tyage, L Tewari

Abstract


In this study, we investigated erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities as antioxidant enzymes and malondialdehyde (MDA) as a sign of lipid peroxidation inAIH patients, along with routine parameters of liver disease. Present investigations were carried out to evaluate these special parameters in patients with clinical history ofAIH
and to assess the utility of these parameters as diagnostic/ prognostic indices of liver function and to correlate with special parameters with routine liver function tests (LFT). SOD, CAT, and MDA along with routine LFT was estimated in 25 patients withAIH and 25 samples from healthy voluntary blood donors served as control group. Routine LFT was estimated by standard clinical chemistry procedure on autoanalyzer and SOD, CAT
and MDA were estimated by NBT reduction, H202 reduction, and TBA method, respectively. In patient group, erythrocyte SOD and CAT activities were strongly positive correlated with MDA concentration. These findings also provide a theoretical basis for the development of novel therapeutic strategies such as supplementation of certain specific enzymatic and/or non enzymatic antioxidants.

Keywords: Acute infective hepatitis;Catalase; Liver Function Tests;Malondialdehyde; Superoxide dismutase.




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